Brain creatine concentrations are associated with sex and symptom severity after concussion: a cross-sectional MR-spectroscopy investigation of adolescents with concussion
Post-concussion sex differences in creatine concentrations were detected, as higher creatine levels moderately correlated with patient-reported outcomes. Creatine may reflect altered energy dynamics in the brain. The absence of a non-injured control group limits determination of whether these differences are concussion-specific or reflective of baseline physiology.
Authors
- Aubrey Armento (ORCID: https://orcid.org/0000-0002-7618-6417)
- David R. Howell (ORCID: https://orcid.org/0000-0002-2955-0191)
- Katherine L. Smulligan (ORCID: https://orcid.org/0000-0002-9060-868X)
- Jessie R. Oldham (ORCID: https://orcid.org/0000-0003-2801-2110)
- Carson Keeter
- Katie Breedlove
- Alexander Lin (ORCID: https://orcid.org/0000-0002-3490-0301)
- Julie M. Wilson (ORCID: https://orcid.org/0000-0003-2510-962X)
- Ved Hatolkar
Institutions
- Brigham and Women's Hospital (US)
- Virginia Commonwealth University (US)
- Children's Hospital Colorado (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Brain Injury
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1080/02699052.2025.2612037
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00