Gene therapy for hereditary deafness: progress, achievements and future challenges

Inner-ear gene therapy has moved from an experimental concept to a clinically validated treatment. AAV-OTOF success opens the door to extending gene therapy to a broad spectrum of auditory and vestibular disorders, heralding a new era of restorative medicine for deafness.

Authors

Kaifan Xu
Yun Xiao
Haibo Wang (ORCID: https://orcid.org/0000-0003-0108-2311)
Xiujuan Xia
L Xu

Institutions

Shandong Provincial Hospital (CN)

Publication Details

Journal: Acta Oto-Laryngologica
Published: 2026-01-06
DOI: https://doi.org/10.1080/00016489.2025.2596867
Primary Topic: Hearing, Cochlea, Tinnitus, Genetics
Type: article
Field-Weighted Citation Impact: 0.00

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article

Gene therapy for hereditary deafness: progress, achievements and future challenges

Kaifan Xu, Yun Xiao, Haibo Wang, Xiujuan Xia et al.

Jan 6, 2026

Acta Oto-Laryngologica

Hearing, Cochlea, Tinnitus, Genetics

article

Gene therapy for hereditary deafness: progress, achievements and future challenges

Kaifan Xu, Yun Xiao, Haibo Wang, Xiujuan Xia, L Xu

January 6, 2026article en

Abstract

Acta Oto-Laryngologica

Shandong Provincial Hospital (CN)

Openalex Percentile: Top 95%

Hearing, Cochlea, Tinnitus, Genetics

DOI Source OpenAlex

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Gene therapy for hereditary deafness: progress, achievements and future challenges — Kaifan Xu, Yun Xiao, et al. · Acta Oto-Laryngologica (2026) | TGRS Research Map | TGRS