Integrative analysis of bulk and single-cell transcriptomics identifies factors related to immunosuppressive microenvironment to predict unfavorable prognosis in inflammatory breast cancer
This study identifies GZMB and SPP1 as potential immunosuppressive-related prognostic biomarkers in IBC patients, reveals the key role of plasmacytoid dendritic cells in remodeling of immunosuppressive microenvironment in IBC.
Authors
- R Zhang
- Xiaoduo Li (ORCID: https://orcid.org/0000-0003-4279-1763)
- Heyan Chen (ORCID: https://orcid.org/0000-0002-6642-8435)
- Y. Zhang
- Jianjun He
- Kexuan Feng
- Xiaoqian Li
- Huimin Zhang
- Junjie Liu
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1727590
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 22.24
Funders
- National Natural Science Foundation of China