Effectiveness of thiazide diuretics in patients with hypertension: a systematic review and meta-analysis

HCTZ and CTD showed comparable efficacy in terms of cardiovascular outcomes. Nevertheless, HCTZ appeared to have a safer profile, with a lower incidence of electrolyte imbalances, such as hypokalemia and hyponatremia, compared to CTD.

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Publication Details

Journal
Annals of Medicine and Surgery
Published
2026-01-06
DOI
https://doi.org/10.1097/ms9.0000000000004668
Primary Topic
Blood Pressure and Hypertension Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Effectiveness of thiazide diuretics in patients with hypertension: a systematic review and meta-analysis

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Blood Pressure and Hypertension Studies
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Effectiveness of thiazide diuretics in patients with hypertension: a systematic review and meta-analysis

Nisha Devi, Sadia Manan, Waseem Raza, Taimoor Ashraf, Shah Dev, Iqra Maryam, Sayed Jawad, Maheen Jabbar, Muskan Turesh, Fnu Nancy, FNU Chandni, Rabia Bint I Zafar, Fatima Jabbar, Deepa Bai, Zara Naveed
article en

Abstract

HCTZ and CTD showed comparable efficacy in terms of cardiovascular outcomes. Nevertheless, HCTZ appeared to have a safer profile, with a lower incidence of electrolyte imbalances, such as hypokalemia and hyponatremia, compared to CTD.

Annals of Medicine and SurgeryVol. 88(2)
Shaheed Benazir Bhutto University (PK), Jinnah Postgraduate Medical Center (PK), Karachi Medical and Dental College (PK), Nishtar Medical College and Hospital (PK), Kabul University (AF), Isra University (PK), Jinnah Sindh Medical University (PK), Kabul University of Medical Sciences Abu Ali Ibn Sina (AF), Shaheed Mohtarma Benazir Bhutto Medical University (PK), Dow University of Health Sciences (PK), Bahria University (PK), Sukkur IBA University (PK), Ziauddin University (PK)
Good health and well-being
Openalex Percentile: Top 95%
Blood Pressure and Hypertension Studies
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