Gender-based differences in telomere attrition and long-term respiratory dysfunction in COVID-19 ICU survivors one year post-infection: implications for aging-associated pulmonary decline

These findings underscore the role of telomere attrition as a sex-specific biomarker of aging-associated pulmonary vulnerability in the aftermath of critical COVID-19 illness. RTL may serve as a prognostic marker for long-term respiratory sequelae, potentially guiding risk stratification and individualized follow-up strategies in post-ICU COVID-19 survivors.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-06
DOI
https://doi.org/10.3389/fimmu.2025.1681454
Primary Topic
Telomeres, Telomerase, and Senescence
Type
article
Field-Weighted Citation Impact
0.00

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article

Gender-based differences in telomere attrition and long-term respiratory dysfunction in COVID-19 ICU survivors one year post-infection: implications for aging-associated pulmonary decline

M Á Alonso Fernández, Eva Manteiga, M José Mallol Poyato, Óscar Martínez-Nieto et al.
Frontiers in Immunology
Telomeres, Telomerase, and Senescence
article

Gender-based differences in telomere attrition and long-term respiratory dysfunction in COVID-19 ICU survivors one year post-infection: implications for aging-associated pulmonary decline

M Á Alonso Fernández, Eva Manteiga, M José Mallol Poyato, Óscar Martínez-Nieto, Rafael BLANCAS, Ana Virseda-Berdices, Raquel Behar-Lagares, Amanda Fernández-Rodríguez, Marcela Homez-Guzmán, Paula Muñoz-García, Salvador Resino, María Ángeles Jiménez-Sousa, Jorge Molina del Pozo
article en

Abstract

These findings underscore the role of telomere attrition as a sex-specific biomarker of aging-associated pulmonary vulnerability in the aftermath of critical COVID-19 illness. RTL may serve as a prognostic marker for long-term respiratory sequelae, potentially guiding risk stratification and individualized follow-up strategies in post-ICU COVID-19 survivors.

Frontiers in ImmunologyVol. 16
Instituto de Salud Carlos III (ES), Hospital Universitario del Tajo (ES), Centro de Investigación Biomédica en Red (ES), Universidad Alfonso X el Sabio (ES), Hospital Universitario del Henares (ES), Hospital Universitario Infanta Cristina (ES)
Instituto de Salud Carlos III
Gender equality
Openalex Percentile: Top 95%
Telomeres, Telomerase, and Senescence
DOIOpen Access PDFOpenAlex
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Gender-based differences in telomere attrition and long-term respiratory dysfunction in COVID-19 ICU survivors one year post-infection: implications for aging-associated pulmonary decline — M Á Alonso Fernández, Eva Manteiga, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS