CBX2 promotes cisplatin resistance in ovarian cancer via SIAH2-mediated β-catenin stabilization and ATG9B-dependent autophagy activation
CBX2 promotes cisplatin resistance in OC via SIAH2-mediated β-catenin stabilization and ATG9B-dependent autophagy activation. Overall, our study reveals a hitherto undocumented role of CBX2 in mediating DDP resistance, providing insights for potential therapeutic biomarkers to overcome DDP resistance in OC.
Authors
- Xinxin Kou
- Zheng Qing Zhao (ORCID: https://orcid.org/0000-0002-5536-0439)
- Yuanjing Hu (ORCID: https://orcid.org/0000-0002-4540-7918)
- Xiaoxia Yang
- Lijie Dong
Institutions
- Tianjin Central Hospital of Gynecology Obstetrics (CN)
- Henan Cancer Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1186/s13048-025-01944-4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00