First functional evidence that a rare germline TP53β variant drives senescence-associated immune suppression and impairs apoptosis and cell migration in breast cancer patients
This study provides supporting evidence for the pathogenicity of the TP53β N340D variant and highlights the importance of integrating functional genomics into PSGT to enhance medical decision-making.
Authors
- Anna‐Mart Engelbrecht (ORCID: https://orcid.org/0000-0003-1469-0148)
- Maritha J. Kotze (ORCID: https://orcid.org/0000-0002-6050-2876)
- Daniel Wilhelm Olivier (ORCID: https://orcid.org/0000-0001-6580-9407)
- Claudia Christowitz (ORCID: https://orcid.org/0000-0002-4780-1978)
- Nicole van der Merwe
Institutions
- National Health Laboratory Service (ZA)
- Stellenbosch University (ZA)
- Tygerberg Hospital (ZA)
Publication Details
- Journal
- Translational Oncology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1016/j.tranon.2025.102616
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00