Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC?
HS is relatively uncommon in this population-based brain bank but is strongly associated with TDP-43 pathology. However, vascular pathology also plays a significant role, particularly in populations with high cardiovascular risk. This limits its predictive value for LATE-NC, even among cognitively impaired individuals. Given the absence of an in vivo biomarker for LATE-NC, further research is needed to determine whether MRI-detectable HS can serve as a reliable surrogate marker for LATE-NC pathology, particularly in genetically diverse populations with multiple comorbidities.
Authors
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Renata Elaine Paraízo Leite (ORCID: https://orcid.org/0000-0002-5878-398X)
- Eduardo Ferriolli (ORCID: https://orcid.org/0000-0002-5028-2451)
- Vítor Ribeiro Paes (ORCID: https://orcid.org/0000-0001-8752-5624)
- Cláudia Kimie Suemoto (ORCID: https://orcid.org/0000-0002-5942-4778)
- Wilson Jacob Filho (ORCID: https://orcid.org/0000-0003-2290-4492)
- Carlos Augusto Pasqualucci
- Alberto Fernando Oliveira Justo
- Caroline Matos Silva
- Roberta Rodriguez
Institutions
- Universidade de São Paulo (BR)
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_107174
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00