Long-term memory in epithelia: transient IFNγ exposure drives stable repression of TFF1 in gastric epithelial cells via epigenetic changes
Overall, our findings show that transient inflammatory signals cause durable gene silencing through epigenetic remodeling, revealing how chronic inflammation can reprogram epithelial cells and promote cancer, while suggesting strategies to reverse these effects.
Authors
- Fátima María Mentucci
- Antonia Voli (ORCID: https://orcid.org/0009-0000-2410-8081)
- Martina Pannetta
- Francesco Boccellato (ORCID: https://orcid.org/0000-0001-6013-7154)
- Daniela Eletto (ORCID: https://orcid.org/0000-0001-6967-1812)
- Silvana Morello (ORCID: https://orcid.org/0000-0002-6541-0997)
- Caterina Giraulo
- A.M. Porta
- Alessandra Tosco
- Alfonso Finizio
Institutions
- University of Salerno (IT)
- Ludwig Cancer Research (GB)
- Ospedale Santa Maria (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1731220
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Salerno