Inadvertent Administration of Oxytocin via Epidural

A patient at our institution was admitted to Labor & Delivery at 41-weeks' gestation for augmentation of early labor for spontaneous rupture of membranes. The anesthesia team placed an epidural catheter and initiated an infusion of bupivacaine with fentanyl for pain management. During nursing shift change several hours later, staff found oxytocin connected to the patient's epidural catheter. A root cause analysis identified that a combination of human error, workflow inefficiencies, and technology challenges contributed to this error. Because the neuraxial and oxytocin infusion bags were the same size, the Department of Pharmacy recommended switching oxytocin infusion bags to a more distinct size. We summarize the literature on inadvertent neuraxial medication infusions, which can lead to devastating consequences. While this patient experienced no adverse effects, we present this case as a cautionary case study to highlight the need for system-level interventions to enhance patient safety.

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Publication Details

Journal
Hospital Pharmacy
Published
2026-01-05
DOI
https://doi.org/10.1177/00185787251408703
Primary Topic
Patient Safety and Medication Errors
Type
article
Field-Weighted Citation Impact
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article

Inadvertent Administration of Oxytocin via Epidural

Karolina Brook, William R. Vincent, R Achu-Lopes, Alexandra Tcherepanova et al.
Hospital Pharmacy
Patient Safety and Medication Errors
article

Inadvertent Administration of Oxytocin via Epidural

Karolina Brook, William R. Vincent, R Achu-Lopes, Alexandra Tcherepanova, Mohamed T. Sarg, Niamh OGrady
article en

Abstract

A patient at our institution was admitted to Labor & Delivery at 41-weeks' gestation for augmentation of early labor for spontaneous rupture of membranes. The anesthesia team placed an epidural catheter and initiated an infusion of bupivacaine with fentanyl for pain management. During nursing shift change several hours later, staff found oxytocin connected to the patient's epidural catheter. A root cause analysis identified that a combination of human error, workflow inefficiencies, and technology challenges contributed to this error. Because the neuraxial and oxytocin infusion bags were the same size, the Department of Pharmacy recommended switching oxytocin infusion bags to a more distinct size. We summarize the literature on inadvertent neuraxial medication infusions, which can lead to devastating consequences. While this patient experienced no adverse effects, we present this case as a cautionary case study to highlight the need for system-level interventions to enhance patient safety.

Hospital Pharmacy
Boston University (US), Boston Medical Center (US)
Decent work and economic growth
Openalex Percentile: Top 96%
Patient Safety and Medication Errors
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Inadvertent Administration of Oxytocin via Epidural — Karolina Brook, William R. Vincent, et al. · Hospital Pharmacy (2026) | TGRS Research Map | TGRS