The 2025 KDIGO guideline on the management of nephrotic syndrome in children: a comment of the European Renal Association Immunonephrology Working Group

Despite advances and therapeutic progress, nephrotic syndrome (NS) in childhood remains challenging due to its heterogeneous presentation, variable response to treatment and the potential of adverse long-term kidney outcomes. The recently published KDIGO 2025 clinical practice guideline for the management of NS in children refines the definitions of relapse, infrequently- and frequently-relapsing NS and steroid-resistant NS. Herein we describe the revised definitions, summarize the key updates of the KDIGO 2025 guidelines and comment on the new treatment algorithm from a European viewpoint, highlighting the need for individualized approaches to minimize toxicity and optimize long-term kidney outcomes in NS in children.

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Publication Details

Journal
Clinical Kidney Journal
Published
2025-12-04
DOI
https://doi.org/10.1093/ckj/sfaf381
Primary Topic
Renal Diseases and Glomerulopathies
Type
article
Field-Weighted Citation Impact
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article

The 2025 KDIGO guideline on the management of nephrotic syndrome in children: a comment of the European Renal Association Immunonephrology Working Group

Eleni Frangou, Andreas Kronbichler, Luis Fernando Quintana, Sarah Margaret Moran et al.
Clinical Kidney Journal
Renal Diseases and Glomerulopathies
article

The 2025 KDIGO guideline on the management of nephrotic syndrome in children: a comment of the European Renal Association Immunonephrology Working Group

Eleni Frangou, Andreas Kronbichler, Luis Fernando Quintana, Sarah Margaret Moran, Marina Vivarelli, Şafak Mirioğlu, Jürgen Floege, Fernando Caravaca-Fontán, Stefanie Steiger, Annette Bruchfeld, Y K Onno Teng, Kate I Stevens
article en

Abstract

Despite advances and therapeutic progress, nephrotic syndrome (NS) in childhood remains challenging due to its heterogeneous presentation, variable response to treatment and the potential of adverse long-term kidney outcomes. The recently published KDIGO 2025 clinical practice guideline for the management of NS in children refines the definitions of relapse, infrequently- and frequently-relapsing NS and steroid-resistant NS. Herein we describe the revised definitions, summarize the key updates of the KDIGO 2025 guidelines and comment on the new treatment algorithm from a European viewpoint, highlighting the need for individualized approaches to minimize toxicity and optimize long-term kidney outcomes in NS in children.

Clinical Kidney JournalVol. 19(1)
Linköping University (SE), Karolinska University Hospital (SE), Innsbruck Medical University (AT), University of Nicosia (CY), National and Kapodistrian University of Athens (GR), University College Cork (IE), Leiden University Medical Center (NL), Cork University Hospital (IE), Karolinska Institutet (SE), Research Institute Hospital 12 de Octubre (ES), Limassol General Hospital (CY), Hospital Clínic de Barcelona (ES), Universitätsklinikum Aachen (DE), Bambino Gesù Children's Hospital (IT), Queen Elizabeth University Hospital (GB), Istanbul University (TR), Universitat de Barcelona (ES), Ludwig-Maximilians-Universität München (DE), RWTH Aachen University (DE)
Openalex Percentile: Top 29%
Renal Diseases and Glomerulopathies
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