Development of a Novel Liquid Chromatography Coupled to Multiple Reaction Monitoring (LC-MRM) Assay for the Quantification of Neurofilament Light Chain in Cerebrospinal Fluid and Comparison with Ultra-Sensitive Immunoassay: A Step toward Standardizat

A new IP-LC-MS/MS method using a SI-traceable calibrator was developed, and analytically and clinically validated. Comparison between available immunoassays resulted in great correlation but biases were identified reinforcing the need of standardization for Nf-L measurement.

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Publication Details

Journal
Clinical Chemistry
Published
2025-12-02
DOI
https://doi.org/10.1093/clinchem/hvaf180
Citations
1
Primary Topic
Multiple Sclerosis Research Studies
Type
article
Field-Weighted Citation Impact
1.47
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article

Development of a Novel Liquid Chromatography Coupled to Multiple Reaction Monitoring (LC-MRM) Assay for the Quantification of Neurofilament Light Chain in Cerebrospinal Fluid and Comparison with Ultra-Sensitive Immunoassay: A Step toward Standardizat

Jérôme Vialaret, Salomé Coppens, Giles Drinkwater, Luise Luckau et al.
1 citations
Clinical Chemistry
Multiple Sclerosis Research Studies
1.47
article

Development of a Novel Liquid Chromatography Coupled to Multiple Reaction Monitoring (LC-MRM) Assay for the Quantification of Neurofilament Light Chain in Cerebrospinal Fluid and Comparison with Ultra-Sensitive Immunoassay: A Step toward Standardizat

Jérôme Vialaret, Salomé Coppens, Giles Drinkwater, Luise Luckau, Etienne Mondésert, Christophe Hirtz, Sylvain Lehmann
article en
1 citations

Abstract

A new IP-LC-MS/MS method using a SI-traceable calibrator was developed, and analytically and clinically validated. Comparison between available immunoassays resulted in great correlation but biases were identified reinforcing the need of standardization for Nf-L measurement.

Clinical Chemistry
Inserm (FR), Université de Montpellier (FR), National Measurement Laboratory (AU)
Partnerships for the goals
Openalex Percentile: Top 13%
Multiple Sclerosis Research Studies
1.47
DOIOpen Access PDFOpenAlex
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Development of a Novel Liquid Chromatography Coupled to Multiple Reaction Monitoring (LC-MRM) Assay for the Quantification of Neurofilament Light Chain in Cerebrospinal Fluid and Comparison with Ultra-Sensitive Immunoassay: A Step toward Standardizat — Jérôme Vialaret, Salomé Coppens, et al. · Clinical Chemistry (2025) | TGRS Research Map | TGRS