Metabolomic profiling of varicocele-induced male infertility: insights from spermatic vein blood analysis
Untargeted metabolomics highlighted D-aspartic acid overexpression as a potential contributor to infertility in VC patients. This study provided only limited support for the retrograde reflux theory of renal and adrenal metabolites, while offering additional evidence consistent with the oxidative stress hypothesis. Oxidative stress-related metabolites may represent potential candidate diagnostic and therapeutic targets for VC-induced infertility.
Authors
- Chao Qin (ORCID: https://orcid.org/0000-0002-3766-771X)
- Shuai Wang (ORCID: https://orcid.org/0000-0003-0893-2534)
- Xinghan Yan
- Yanru Wang (ORCID: https://orcid.org/0000-0001-8272-2450)
- Ninghong Song
- Da Zhong
- Xiyi Wei
- Zijie Yu
- Xi Zhang
- Wenchuan Shao
Institutions
- Jiangsu Cancer Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fendo.2025.1682362
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Postdoctoral Science Foundation of Jiangsu Province