Exploring the mechanism of action of Kaixin San in treating dementia based on network pharmacology and molecular docking

Kaixin San likely mitigates dementia through flavonoid/xanthone-mediated modulation of core targets (AKT1, STAT3, ESR1) and critical pathways (ErbB, PI3K-AKT), thereby alleviating behavioral deficits, conferring neuroprotection, and attenuating amyloid-β (Aβ) deposition.

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Publication Details

Journal
Medicine
Published
2026-01-02
DOI
https://doi.org/10.1097/md.0000000000046583
Primary Topic
Computational Drug Discovery Methods
Type
article
Field-Weighted Citation Impact
0.00
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article

Exploring the mechanism of action of Kaixin San in treating dementia based on network pharmacology and molecular docking

Z. Zhang, Shuyuan Liu
Medicine
Computational Drug Discovery Methods
article

Exploring the mechanism of action of Kaixin San in treating dementia based on network pharmacology and molecular docking

Z. Zhang, Shuyuan Liu
article en

Abstract

Kaixin San likely mitigates dementia through flavonoid/xanthone-mediated modulation of core targets (AKT1, STAT3, ESR1) and critical pathways (ErbB, PI3K-AKT), thereby alleviating behavioral deficits, conferring neuroprotection, and attenuating amyloid-β (Aβ) deposition.

MedicineVol. 105(1)
Liaoning University of Traditional Chinese Medicine (CN), Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
Openalex Percentile: Top 94%
Computational Drug Discovery Methods
DOIOpen Access PDFOpenAlex
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Exploring the mechanism of action of Kaixin San in treating dementia based on network pharmacology and molecular docking — Z. Zhang, Shuyuan Liu · Medicine (2026) | TGRS Research Map | TGRS