Machine learning to optimize the diagnostic performance of natriuretic peptides for acute heart failure across age groups
The diagnostic performance of guideline-recommended thresholds of NT-proBNP varies significantly with age. A decision-support tool incorporating NT-proBNP with age as a continuous variable provides a more consistent and accurate approach.
Authors
- Martin Möckel (ORCID: https://orcid.org/0000-0002-7691-3709)
- Gordon W. Moe
- K K Lee
- Michael Behnes (ORCID: https://orcid.org/0000-0001-5970-0093)
- Alfons Gegenhuber
- J. Wiemer
- Maria Belkin (ORCID: https://orcid.org/0000-0003-4643-8473)
- James Louis Januzzi (ORCID: https://orcid.org/0000-0002-8338-1798)
- Hanna K. Gaggin (ORCID: https://orcid.org/0000-0001-8068-6134)
- Michael Neumaier (ORCID: https://orcid.org/0000-0003-0136-3754)
- Desiree Nadine Wussler (ORCID: https://orcid.org/0000-0002-1793-5297)
- Giovanni Albano (ORCID: https://orcid.org/0009-0001-0062-5057)
- Yigal M. Pinto
- Michele Bombelli (ORCID: https://orcid.org/0000-0002-8459-711X)
- Luna Gargani
- Philipp Bahrmann (ORCID: https://orcid.org/0000-0002-5894-3402)
- J R Rutten
- Stephen L. Seliger (ORCID: https://orcid.org/0000-0002-1693-0734)
- Camille Chenevier-Gobeaux
- Dimitrios Doudesis
- Christian Mueller
- Ibrahim Akin
- Guido Grassi
- Y.-É. Claessens (ORCID: https://orcid.org/0000-0001-7506-3063)
- Irwani Ibrahim
- Carlos Fernando
- Antoni Bayes-Genis
- John J. V. McMurray
- Christopher deFilippi
- Peiman Nazerian
- Thomas Mueller
- A Mark Richards
- Daniel Perez Vicencio
- Nicholas L Mills
- Pedro Lopez Ayala
- Nicola R Pugliese
- Alexander J F Thurston
Institutions
- University of Pisa (IT)
- University of Maryland, Baltimore (US)
- St. Michael's Hospital (CA)
- Harvard University (US)
- Radboud University Nijmegen (NL)
- Heidelberg University (DE)
- Princess Grace Hospital Centre (MC)
- Vancouver General Hospital (CA)
- University Medical Center (US)
- Radboud University Medical Center (NL)
- Cardiovascular Institute Hospital (JP)
- British Heart Foundation (GB)
- Massachusetts General Hospital (US)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- National University Heart Centre Singapore (SG)
- Amsterdam Neuroscience (NL)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Institute for Biomedicine (IT)
- National University Hospital (SG)
- Hospital Universitari Germans Trias i Pujol (ES)
- University Medical Centre Mannheim (DE)
- Christ University (IN)
- Amsterdam University of Applied Sciences (NL)
- University of Milano-Bicocca (IT)
- Thermo Fisher Scientific (Israel) (IL)
- Charité - Universitätsmedizin Berlin (DE)
- University of Glasgow (GB)
- University of Otago (NZ)
- University of Amsterdam (NL)
- University of Edinburgh (GB)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1093/eschf/xvaf006
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Abbott Laboratories
- Israel Cancer Research Fund
- Pfizer
- Alexion Pharmaceuticals
- British Heart Foundation
- Novo Nordisk
- Schweizerische Herzstiftung
- Medical Research Council