Senolytic Changes in Murine Arteriovenous Fistulas with CKD
These data support established markers of AVF failure like matrix-metalloproteinases and monocyte chemokines and identify potential novel modulators of AVF survival that may inform senolytic strategies to improve patency. In summary, this study reveals for the first time the chronological progression of vascular senescence in the AVF of uremic mice.
Authors
- James L. Kirkland (ORCID: https://orcid.org/0000-0003-1676-4905)
- Dominik Saul
- Sreenivasulu Kilari (ORCID: https://orcid.org/0000-0002-9149-7360)
- Sanjay Misra
- N. Leigh Anderson (ORCID: https://orcid.org/0000-0003-2699-3998)
- Prabh Singh
- Jamie Kane (ORCID: https://orcid.org/0009-0005-0129-0075)
- Alaura Lemieux
- Tamar Tchkonia
Institutions
- Cedars-Sinai Medical Center (US)
- Mayo Clinic (US)
- WinnMed (US)
- Robert Bosch Hospital (DE)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Kidney360
- Published
- 2026-01-06
- DOI
- https://doi.org/10.34067/kid.0000001104
- Primary Topic
- Central Venous Catheters and Hemodialysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00