Association between Classical Monocytes and Cardiovascular Events in Patients with Coronary Heart Disease

Background: Worldwide, coronary artery disease (CAD) ranks high among the primary causes of mortality. Objectives: This study aimed to examine the relationship between monocyte subcohorts and the occurrence of CV (cardiovascular) events (acute coronary syndrome, revascularisation, and non-fatal myocardial infarction) as well as the serum levels of these subcohorts in cases with confirmed CAD. Patients and methods: The Cardiology Department of Menoufia University Hospital conducted this case-control research on 100 adult persons as a control cohort study. The 100 persons were divided into two equal groups: healthy persons and cardiac patients. Echocardiography, cardiac angiography and monocytes by flow cytometry were done. Results: In the univariate logistic regression analysis, the following variables were identified as significant predictors of CAD and markers of case-control relationships: age, body mass index (BMI), smoking, hypertension, diabetes mellitus, dyslipidemia, total cholesterol, triglycerides, creatinine, triglycerides, lymphocytes, and monocytes. According to the findings of the multivariate logistic regression analysis, monocytes were shown to be the only significant predictor of CAD, and they demonstrated the ability to distinguish between the two categories. Conclusions: Classical monocyte numbers were noticeably greater in CAD cases, indicating a link between monocyte-driven inflammation and CV risk. Classical monocytes and the occurrence of CV events in CAD cases were significantly correlated.