NOS2/ARG1 axis and immune cell ratios as promising prognostic and predictive biomarkers for Cetuximab combined with chemotherapy in wt-KRAS human colorectal cancer
Our study highlights the pivotal role of the NOS2/ARG1 axis in local immune infiltration, systemic inflammation, and clinical outcomes in mCRC patients receiving cetuximab. For the first time, we propose a novel combined score integrating NO, arginase, SII, and SIRI as simple, accessible, and non-invasive prognostic and predictive markers. Our findings may open new avenues for patient stratification and treatment optimization in precision oncology research.
Authors
- Nadira Delhem (ORCID: https://orcid.org/0000-0001-5335-4222)
- Sarra Benkhelifa (ORCID: https://orcid.org/0000-0002-9062-5033)
- Assia Galleze
- Sonia Ait Younes
- S. Belhadef
- Houda Belguendouz (ORCID: https://orcid.org/0000-0003-3641-4291)
- Djehane Houria Mataam
- Touil-Boukoffa Chafia
- Hayet Rafa
- Olivier Morales
- Anissa Benali
- Wafa Khelaifia
- Ryad Trari
- Sabrina Bouhara
- Hassan Mahfouf
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of Algiers Benyoucef Benkhedda (DZ)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Higher National Veterinary School (DZ)
- Onco Lille (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1700487
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00