Green synthesis of phosphoryl pyran employing multicomponent reaction of alkyl bromides

An effective one-pot synthesis of dialkoxyphosphoryl-2-oxo-2H-pyran derivatives by three-component reaction of alky bromides and dialkylacetylenedicarboxylates in the presence of trialkyl phosphite is described. The reactions were performed under solvent-free conditions at 50oC and neutral conditions and provided good yields of products.

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Publication Details

Published
2025-03-28
DOI
https://doi.org/10.82361/iranjoc.2025.1202876
Primary Topic
Multicomponent Synthesis of Heterocycles
Type
article
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article

Green synthesis of phosphoryl pyran employing multicomponent reaction of alkyl bromides

IAU
Multicomponent Synthesis of Heterocycles
article

Green synthesis of phosphoryl pyran employing multicomponent reaction of alkyl bromides

IAU
article en

Abstract

An effective one-pot synthesis of dialkoxyphosphoryl-2-oxo-2H-pyran derivatives by three-component reaction of alky bromides and dialkylacetylenedicarboxylates in the presence of trialkyl phosphite is described. The reactions were performed under solvent-free conditions at 50oC and neutral conditions and provided good yields of products.

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Multicomponent Synthesis of Heterocycles
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Green synthesis of phosphoryl pyran employing multicomponent reaction of alkyl bromides — IAU · (2025) | TGRS Research Map | TGRS