Single-cell transcriptome analysis of patient-derived organoids captures inter- and intratumor heterogeneity and uncovers targetable pathways in high grade serous ovarian cancer
PDOs maintain the inter- and intra-tumoral cellular heterogeneity of HGSOC. Chemotherapy targets proliferative cell subclusters, sparing non-proliferative ones. Dependency on OXPHOS represents an actionable vulnerability in PDOs, which can be exploited to hijack chemoresistance. Sequential chemotherapy and immunotherapy may also improve clinical response of HGSOC patients.
Authors
- Roberta Mastrantonio (ORCID: https://orcid.org/0000-0002-1764-457X)
- Claudio Sette (ORCID: https://orcid.org/0000-0003-2864-8266)
- Giovanni Scambia (ORCID: https://orcid.org/0000-0002-9503-9041)
- Eleonora Cesari (ORCID: https://orcid.org/0000-0002-7499-5165)
- Marco Pieraccioli (ORCID: https://orcid.org/0000-0003-3995-535X)
- Andrea Urbani (ORCID: https://orcid.org/0000-0001-9168-3174)
- A. Minucci
- Alessia Piermattei (ORCID: https://orcid.org/0000-0001-7164-4952)
- Nero Camilla
- Luca Tamagnone
- Eleonora Kristina Scarpone
- Christian Corti
- Anna Fagotti
- Alessandra Ciucci
- Floriana Camarda
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- University of the Sacred Heart (JP)
Publication Details
- Journal
- Drug Resistance Updates
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1016/j.drup.2026.101354
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00