White Matter Hyperintensities Predict Driving Behavior Changes in Preclinical Alzheimer's Disease

WMH in OA significantly impacts driving behavior, leading to latent self-regulation and reduced driving complexity. Cognitive impairment with WMH increases risky driving. Posterior WMH influence suggests a dominant role of AD pathology in driving performance decline. WMH shows potential as a biomarker for identifying individuals at higher risk of unsafe driving and premature driving cessation, highlighting its value in early screening and intervention strategies for road safety among aging populations, particularly those at risk for AD.