Recombinant Thrombomodulin Domain 1 Promotes Diabetic Corneal Wound Healing by Inhibiting HMGB1 Production and NLRP3 Inflammasome
Topical application of rTMD1 promotes corneal epithelial wound healing in diabetic conditions by inhibiting HMGB1/TLR4/NLRP3-mediated inflammation. rTMD1 holds promise as a potential therapeutic agent for diabetic keratopathy, although further studies are needed to validate its clinical efficacy and safety.
Authors
- I‐Chen Peng (ORCID: https://orcid.org/0000-0001-5826-500X)
- Yun Huang (ORCID: https://orcid.org/0000-0003-1549-1669)
- C. S. Kuo
- Hua-Lin Wu
- Kuan-Ying Chen
Institutions
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Mediators of Inflammation
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1155/mi/8089754
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Council