Panduratin A from Boesenbergia rotunda suppresses hepatitis B virus by targeting HNF1α and synergizing with antiviral agents
Panduratin A is a potent anti-HBV compound that acts primarily through HNF1α-dependent suppression of HBV transcription and replication. Its efficacy in combination therapy and in 3D liver models highlights its potential as a promising candidate for future HBV treatment strategies.
Authors
- Pakatip Ruenraroengsak (ORCID: https://orcid.org/0000-0002-4345-9159)
- Piyanoot Thongsri
- Yongyut Pewkliang (ORCID: https://orcid.org/0000-0003-2267-7883)
- Suparerk Borwornpinyo (ORCID: https://orcid.org/0000-0001-6211-3615)
- U Anurathapan
- Adisak Wongkajornsilp (ORCID: https://orcid.org/0000-0002-3965-0997)
- Abhasnee Sobhonslidsuk
- Suradej Hongeng
- Khanit Sa-ngiamsuntorn
Institutions
- Siriraj Hospital (TH)
- Mahidol University (TH)
- Ramathibodi Hospital (TH)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s13020-025-01285-w
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 0.00