Combined effects of mesenchymal stromal cells and antibiotic therapy on Enterobacter ventilator-associated pneumonia in rabbits
MSCs alone did not improve lung bacterial clearance or inflammation resolution in this rabbit VAP model. However, the combination of MSCs with cefepime enhanced lung bacterial clearance and reduced lung IL-6 concentrations, compared with cefepime alone. Further studies are required to elucidate the mechanisms underlying the combined effects of antibiotics and MSCs.
Authors
- Mathieu Blot (ORCID: https://orcid.org/0000-0001-6541-2434)
- Corentin Richard (ORCID: https://orcid.org/0000-0001-9732-0219)
- Marine Jacquier
- Danièle Bensoussan (ORCID: https://orcid.org/0000-0002-1706-1761)
- Caroline Laroye (ORCID: https://orcid.org/0000-0002-2852-8160)
- R. Boidot
- David Masson
- Pierre-Emmanuel Charles
- Sylvie Nguyen
- Delphine Croisier
Institutions
- Centre National de la Recherche Scientifique (FR)
- IDEXX Laboratories (France) (FR)
- Inserm (FR)
- Université de Bourgogne (FR)
- Centre Georges François Leclerc (FR)
- Centre de recherche Translationnelle en Médecine moléculaire (FR)
- Maison des Sciences sociales et des Humanités de Dijon (FR)
- Université de Lorraine (FR)
Publication Details
- Journal
- Respiratory Research
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s12931-025-03457-6
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00