Dose-Dependent Histological Effects of Orlistat on the Stomach and Spleen of High-Fat Diet Male Rats

The specific impact of Orlistat, in conjunction with HFD exposure, on the histomorphology and cellular composition of the stomach and spleen remains a critical area for investigation. This study investigated Orlistat the stomach and spleen in prior research. Male rats were split for five set (five each group): group 1, (C/A) was normal diet; group 2, (C/B): Was given 30% the high fat diet; group 3, (OS-360 mg/kg); group 4, (OS-480 mg/kg); group 5, (OS-600 mg/kg). Rats were administered orally daily for 60 days. The results obtained from stomach tissues that Orlistat induces dose-dependent oxidative stress, showing increased inflammation and potential epithelial disruption and pronounced lamina propria cellularity and mucosal damage with the maximum dose, also in spleen show revealing increased hemosiderin deposition and potential splenic burden and show signs of increased red pulp activity and macrophage accumulation, may not protect against damage caused by a high-fat diet. The Orlistat have adverse stomach and spleen effects and dose-dependent oxidative stress.