Genetic deletion of cytoglobin exacerbates cardiac hypertrophy and inhibits cardiac fibroblast activation independent of changes in blood pressure
Our findings indicate that Cygb plays a protective role in the mouse heart during Ang II-induced cardiac stress. This is the first study detailing the function of Cygb in the heart as a regulator of cardiac hypertrophy. This study also reveals a role for Cygb in regulating cardiac fibroblast activation by Ang II.
Authors
- Kurrim Gilliard
- John J. Schwarz (ORCID: https://orcid.org/0000-0002-8713-4778)
- Harold A. Singer (ORCID: https://orcid.org/0000-0001-8554-3239)
- Le Gia Cat Pham (ORCID: https://orcid.org/0009-0005-4328-2006)
- Sarahann Mistretta
- Frances Jourd'heuil
- David Jourd'heuil
Institutions
- Albany Medical Center Hospital (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-07
- DOI
- https://doi.org/10.64898/2026.01.06.697990
- Primary Topic
- Hemoglobin structure and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00