Scandium-catalyzed asymmetric addition of allenylsilanes to β,γ-unsaturated α-ketoesters: enantioselective synthesis of tertiary homopropargylic allylic alcohols

A scandium catalyzed regio- and enantioselective 1,2-homopropargylic addition of β,γ-unsaturated α-ketoesters was demonstrated, affording enantioenriched tertiary homopropargylic allylic alcohols in good yields with excellent enantioselectivities.