Association of imaging markers and overall burden of cerebral small vessel disease with cognition in COMPASS‐ND

Older adults with greater CSVD burden, as evidenced by multiple MRI markers, exhibit poorer cognition and functional performance across the neurocognitive continuum. Notably, these associations were observed not only for global CSVD but also for both CAA- and HTNA-specific CSVD scores, suggesting the importance of evaluating these specific pathologies when assessing cerebrovascular contributions to cognitive decline.