In Silico Functional and Structural Analysis of STAT4 Variants of Uncertain Significance
The integrative use of the bioinformatic tools employed represents a valuable preliminary step prior to undertaking more complex and resource-intensive functional studies. This complementary strategy strengthens the interpretative framework for VUS, guiding subsequent experimental validation and supporting a structured assessment of variant relevance, particularly in the context of immune-related genes such as <i>STAT4</i>.
Authors
- Itzae Adonaí Gutiérrez-Hurtado (ORCID: https://orcid.org/0000-0001-6174-0609)
- Andrés López-Quintero (ORCID: https://orcid.org/0000-0002-5151-041X)
- Karla Mayela Bravo-Villagra
- José Francisco Muñóz-Valle (ORCID: https://orcid.org/0000-0002-2272-9260)
- Rosa Michel Martínez-Contreras (ORCID: https://orcid.org/0009-0002-4017-645X)
- Alexis Missael Vizcaíno-Quirarte
- Eric Jonathan Maciel-Cruz
Institutions
- Mexican Social Security Institute (MX)
- Universidad de Guadalajara (MX)
Publication Details
- Journal
- Genes
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3390/genes17010072
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00