Predictive value of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio for three-year survival in patients with early esophageal cancer undergoing endoscopic submucosal dissection

NLR, PLR, and MLR are significantly and positively associated with three-year mortality risk in patients with early esophageal cancer undergoing ESD, in either linear or near-linear patterns. These markers also exhibit synergistic interactions with tumor-related clinical features such as location, depth of invasion, and margin status. Among them, PLR demonstrated the best predictive performance. This study provides valuable evidence for postoperative risk assessment and individualized follow-up management in early esophageal cancer patients.