CAR Intrinsic Design Pre-Shapes Transcriptional and Metabolic Networks in CAR T Cells
CAR-intrinsic features, notably co-stimulatory domain choice, define the tonic NF-κB activation tone in resting CAR T cells. Metabolic refueling boosts these baseline states without overstimulation, suggesting it may be especially valuable for weaker CAR constructs. These findings provide a framework for tuning CAR T cell function through combinatorial design strategies targeting signaling and metabolism.
Authors
- Didem Ağaç Çobanoğlu (ORCID: https://orcid.org/0000-0002-3493-7024)
- Devon J. Boland (ORCID: https://orcid.org/0000-0001-8903-9718)
- Xiaotong Song (ORCID: https://orcid.org/0009-0001-3561-5852)
- Samantha Franklin
- Yue Hu (ORCID: https://orcid.org/0009-0005-2192-846X)
Institutions
- Texas Medical Center (US)
- Texas A&M University System (US)
- Texas A&M University (US)
Publication Details
- Journal
- Metabolites
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3390/metabo16010052
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense