Minimal Gain in Prognostic Certainty for Patients With Hematologic Malignancies Over 2 Weeks of Intensive Care: An Analysis to Inform Time-Limited Trials
In patients with hematologic malignancies admitted to the ICU, prognostic certainty about long-term survival increased little during in the first 2 weeks of ICU admission, aside from increases in prognostic certainty due to early mortality. Despite the use of rich ICU datasets and different state-of-the-art modeling strategies, overall model performance was modest, suggesting that prognosis in this population is largely driven by disease-related and patient-specific factors beyond the ICU course.
Authors
- Tariq A. Dam (ORCID: https://orcid.org/0000-0003-1631-2378)
- Rolf K. Gigengack (ORCID: https://orcid.org/0000-0003-2162-0674)
- Paul Elbers (ORCID: https://orcid.org/0000-0003-0447-6893)
- Marcella S. Müller (ORCID: https://orcid.org/0000-0003-3884-1908)
- Ameet R. Jagesar (ORCID: https://orcid.org/0000-0002-1826-9900)
- Martijn Otten (ORCID: https://orcid.org/0000-0003-3409-3551)
- Harm‐Jan de Grooth (ORCID: https://orcid.org/0000-0002-7499-076X)
- B. J. Biemond
- Monika C. Kerckhoffs (ORCID: https://orcid.org/0000-0003-3280-7768)
- Laurens A. Biesheuvel (ORCID: https://orcid.org/0009-0008-1006-5090)
- A. R. J. Girbes
- Paul Hilders
- Bob J. H. van Kempen
- Brittney van der Woude
Institutions
- University Medical Center Utrecht (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1097/ccm.0000000000007006
- Citations
- 1
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 31.52