One Size Does Not Fit All: The Need for Sex-Specific Precision Medicine in Diabetes Technology.

Incorporating sex-specific factors in diabetes research and treatment is essential for advancing precision medicine. There are critical gaps in understanding and applying sex-related differences. Female-specific diabetes pathophysiology manifests in three major areas: life cycle phases (including puberty, pregnancy, and menopause), lifestyle factors (such as responses to nutrition and physical activity), and insulin pharmacology. These elements significantly affect insulin sensitivity and glycemic control in women, yet are frequently underrepresented or ignored in both research and clinical practice. Greater research and clinical focus across these domains is needed to better understand and address sex-based differences in diabetes. Identifying and filling evidence gaps will support more systematic and effective care.

Authors

Publication Details

Journal
Apollo (University of Cambridge)
Published
2025-05-25
DOI
https://doi.org/10.17863/cam.124279
Primary Topic
Sex and Gender in Healthcare
Type
article
Field-Weighted Citation Impact
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article

One Size Does Not Fit All: The Need for Sex-Specific Precision Medicine in Diabetes Technology.

THOMAS ZUEGER, Jane E. Yardley, Carol J. Levy, Temiloluwa Prioleau et al.
Apollo (University of Cambridge)
Sex and Gender in Healthcare
article

One Size Does Not Fit All: The Need for Sex-Specific Precision Medicine in Diabetes Technology.

THOMAS ZUEGER, Jane E. Yardley, Carol J. Levy, Temiloluwa Prioleau, Tim Gunn, CHARLOTTE K. BOUGHTON, Dawn Adams, Chiara Fabris, Claudia Eberle, Cameron Keighron, David Burren, Stefanie Hossmann, Hanne Ballhausen, OTHMAR MOSER, Olga Gusyatiner, G Faber-Heinemann, Valentina V. Huwiler, Trevor Hastings, Aisling Ann O’Kane, Tanja Thybo, Maria L. Balmer, Lutz Heinemann, Deniz Cengiz, Vincent Braunack-Mayer, Susanne Tan, Saira Khan-Gallo, Elke Fröhlich-Reiterer, Martina Rothenbühler, Nick Oliver, David C Klonoff, Anne Bonhoure, Lia Bally, Maya Friedman, Julia K Mader
article en

Abstract

Incorporating sex-specific factors in diabetes research and treatment is essential for advancing precision medicine. There are critical gaps in understanding and applying sex-related differences. Female-specific diabetes pathophysiology manifests in three major areas: life cycle phases (including puberty, pregnancy, and menopause), lifestyle factors (such as responses to nutrition and physical activity), and insulin pharmacology. These elements significantly affect insulin sensitivity and glycemic control in women, yet are frequently underrepresented or ignored in both research and clinical practice. Greater research and clinical focus across these domains is needed to better understand and address sex-based differences in diabetes. Identifying and filling evidence gaps will support more systematic and effective care.

Apollo (University of Cambridge)
Zero hunger
Openalex Percentile: Top 24%
Sex and Gender in Healthcare
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