Bidirectional Mendelian Randomization Analysis of 338 Cerebrospinal-Fluid Metabolites and Cluster-Headache Risk
This bidirectional MR study provides the first genetic evidence linking central metabolic alterations to CH susceptibility. While these results highlight potential metabolic biomarkers and mechanistic pathways, the findings remain preliminary due to modest statistical power and should be replicated in larger and ethnically diverse cohorts.
Authors
- Shaokang Huang
- Jinli Zhou
- Danhua Yu
- Jinhui Song
- Weiwei Chen
- Xuewei Yang
- Weifei Yu
Institutions
- Second Military Medical University (CN)
- Changhai Hospital (CN)
- Yichang Central People's Hospital (CN)
- Yiwu Science and Technology Research Institute (CN)
- Yuxian People's Hospital (CN)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/jpr.s550160
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00