Neuroticism and brain structure: a large‐scale brain‐wide association study with mediation by health conditions
Neuroticism was associated with widespread structural differences, including lower volumes in frontal and limbic regions and impaired microstructure in the thalamic radiations, partially mediated by mental and vascular conditions. Further research is needed to strengthen evidence of causality in these pathways and explore their roles in cognitive decline and dementia.
Authors
- Cornelia M. van Duijn (ORCID: https://orcid.org/0000-0002-2374-9204)
- Anya Topiwala (ORCID: https://orcid.org/0000-0002-8408-0372)
- Thomas J. Littlejohns (ORCID: https://orcid.org/0000-0003-1177-6923)
- David John Hunter (ORCID: https://orcid.org/0000-0003-3197-752X)
- Yaqing Gao
- Najaf Amin
Institutions
- University of Oxford (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104658
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00