Structural brain MRI abnormalities in SCN1A-, SCN2A-, SCN3A-, and SCN8A-related epilepsies: a cohort study
Contrary to earlier assumptions, structural MRI abnormalities are common in <i>SCN</i>-related epilepsies, particularly in <i>SCN2A</i>-and <i>SCN8A</i>-related epilepsies. MRI may aid in the diagnosis, phenotypic stratification, and prognostication of genetic epilepsy involving voltage-gated sodium channels.
Authors
- J. Lee
- Heeseung Cho
- Daehyun Kim (ORCID: https://orcid.org/0000-0002-5277-0862)
- Ara Ko
- Na-Young Shin
- H. K. Kim
- Hoon-chul Kang
- Daewoong Ahn
- Lip-Yuen Teng
- Hyeon Deok Sang
Institutions
- Yonsei University (KR)
- Severance Hospital (KR)
- Hospital Tuanku Ja’afar (MY)
- Yonsei University Health System (KR)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fneur.2025.1706132
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Yonsei University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- Yonsei University College of Medicine