Synthesis and study of antioxidant activity of pyrimidine derivatives: Cu@KF/clinoptilolite nanoparticles promoted

The preparation of pyrrolo pyrimidinone derivatives were performed by using four component reactions of tricarbonyl compounds, imine derivatives of aldehydes, activated acetylenic compounds and alkyl bromides in the presence of catalytic amounts of Cu@KF/CP NPs as a high performance catalyst in water at room temperature. In addition, for investigation of antioxidant ability radical trapping by DPPH and reducing power of ferric ion experiments was performed. As a result, synthesized compounds show excellent radical trapping by DPPH and good reducing ability of ferric ion. The current procedure has the benefits for instance excellent yield of reaction, green media and easy separation of product and catalyst.