Hypoxia promotes BCMA loss and a suppressive secretome thereby hindering CAR T cell therapy in multiple myeloma
This study shows that hypoxia diminishes BCMA expression and enhances secretion of immunosuppressive factors, including sEVs, thereby limiting the efficacy of BCMA CAR T cell therapy in MM.
Authors
- Elke De Bruyne (ORCID: https://orcid.org/0000-0003-4012-4617)
- Karine Breckpot (ORCID: https://orcid.org/0000-0003-4331-3480)
- Fien Meeus (ORCID: https://orcid.org/0000-0002-5866-2002)
- Eline Menu
- Kim De Veirman
- Karin Vanderkerken
- Chenggong Tu
- Lauren van den Broecke
- Jack Brons
- Arne Van der Vreken
Institutions
- Vrije Universiteit Brussel (BE)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1186/s40164-025-00732-6
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- Kom op tegen Kanker
- Fondation contre le Cancer