CGRP/TSP1 Signaling Dampens Corneal Inflammation and Fibrosis by Targeting A2M During Corneal Stromal Wound Healing
Our findings indicate that TSP1 and A2M induction represents a conserved stress-protective response to corneal stromal injury. The CGRP/TSP1/A2M signaling axis is critical for modulating stromal inflammation and fibrosis, highlighting its therapeutic potential for enhancing corneal stromal repair.
Authors
- Yizhou Li (ORCID: https://orcid.org/0009-0000-5502-4243)
- Jin Xie (ORCID: https://orcid.org/0000-0002-8915-6233)
- Yan Wang (ORCID: https://orcid.org/0009-0003-5860-2725)
- X. Qi
- Qingjun Zhou (ORCID: https://orcid.org/0000-0002-6109-3445)
- Xinyi Zang
- Ya Li (ORCID: https://orcid.org/0000-0003-3689-0423)
- Qian Guo (ORCID: https://orcid.org/0000-0002-5608-1458)
- Xiaolei Wang
- Yangyang Zhang
- Hongqi Ge
- Lingling Yang
Institutions
- Shandong University (CN)
- Shandong Academy of Pharmaceutical Sciences (CN)
- Shandong Eye Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1167/iovs.67.1.10
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- University of California, Irvine