Soluble neprilysin is associated with myocardial damage and systolic dysfunction in an animal model of doxorubicin-induced cardiotoxicity
Chronic DOX exposure reduces LV NEP protein expression. Elevated serum sNEP is associated with greater early cardiomyocyte injury, while in chronic AIC, it correlates with a more severe decline in cardiac output. These findings suggest sNEP may be a potential biomarker for AIC.
Authors
- Katarzyna Matusik (ORCID: https://orcid.org/0000-0002-6574-4049)
- Karol Borensztejn
- Dorota Sztechman (ORCID: https://orcid.org/0000-0002-7100-2236)
- Łukasz Koperski (ORCID: https://orcid.org/0000-0001-8163-1813)
- Aleksandra Sobiborowicz (ORCID: https://orcid.org/0000-0002-8245-9311)
- Katarzyna Kamińska (ORCID: https://orcid.org/0000-0002-7936-9374)
- Agnieszka Cudnoch-Jędrzejewska
Institutions
- Medical University of Warsaw (PL)
Publication Details
- Journal
- Cardio-Oncology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1186/s40959-025-00397-4
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Warszawski Uniwersytet Medyczny
- Uniwersytet Warszawski