Establishment of Mouse Meibomian Gland Organoids for In Vitro Modeling of Meibomian Gland Dysfunction
We developed mouse MG organoids that exhibited ductal-acinar architecture, sustained lipid production, and maintained stem/progenitor cell expression. Organoids modeled key features of MGD through exposure to IL-1β and can respond to targeted therapy. The system offered a promising platform for MGD research.
Authors
- Z Y Li
- Hongran Zhao (ORCID: https://orcid.org/0000-0001-8571-785X)
- Qunqin Guo
- Qingjun Zhou (ORCID: https://orcid.org/0000-0002-6109-3445)
- Leilei Zhao (ORCID: https://orcid.org/0009-0002-1265-416X)
- Yanlin Zhong (ORCID: https://orcid.org/0000-0001-7828-905X)
- Xiangzheng Zhang
- Lixin Xie
- Jingyu Qu
- Lingling Yang
- Yujing Lin
- Xiaolei Wang
Institutions
- Shandong Eye Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1167/iovs.67.1.6
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00