Pbrm1 Loss Induces a Permissive Chromatin State for Cholangiocytic Differentiation and Cholangiocarcinoma Formation
PBRM1 maintains chromatin accessibility for hepatocyte differentiation-related genes. Its loss promotes differentiation toward cholangiocytes during injury or tumorigenesis, driving iCCA development.
Authors
- Li-Wen Chiou (ORCID: https://orcid.org/0000-0002-5994-1943)
- Jeng Yung-Ming
- Chia-Lang Hsu
- Yi-Ting Fang
- Ching-Yao Yang
- Yu-Lin Jhuang
- Yen-Hsu Cheng
- Ray-Hwang Yuan
- Chia-Hsiang Lee
Institutions
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101720
- Citations
- 1
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 39.15