Cigarette smoke exposure triggers dendritic cell-derived exosome-mediated Th17 and Treg polarization through an autophagy- and necroptosis-associated SIRT1-dependent mechanism in vitro
CSE exposure induces an imbalance in Th17/Treg polarization through a process mediated by DCexos that entails reduced SIRT1 expression, increased necroptosis, and dysregulated autophagy. SIRT1 activation by SRT1720 can attenuate these effects by restoring immune balance and modulating cell death and survival pathways in DCs under CSE exposure.
Authors
- Leilei Ya
- Y. Wei
- Zhaohong Huang (ORCID: https://orcid.org/0000-0001-9470-2318)
- Dongling Luo
- Siyi Ou
- Jifeng Liu
- Chengxuan Ruan
- Qingyun Lin
- Kaiwen Nong
Institutions
- Beihai People's Hospital (CN)
- Liuzhou Maternal and Child Health Hospital (CN)
- Liuzhou General Hospital (CN)
- Beibu Gulf University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1715736
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 22.24
Funders
- National Natural Science Foundation of China
- Guangxi Medical University