Case Report: Perioperative application of trastuzumab deruxtecan in HER2 exon 20 mutation-positive non-small cell lung cancer

This case shows that perioperative treatment with T-DXd could induce tumor regression and sustain remission, while MRD monitoring enables early detection of molecular progression. These findings emphasize the potential of combining T-DXd and MRD monitoring to tailor treatment to improve outcomes in <i>HER2</i>-mutant NSCLC.

Authors

Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
Jiaqi Yang (ORCID: https://orcid.org/0000-0001-8498-0269)
Wenzhu Li (ORCID: https://orcid.org/0000-0003-1966-1151)
Xiaoshu Chai
Zhenzhen Xiao
Lirong Liu

Institutions

Guangzhou University of Chinese Medicine (CN)
Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)

Publication Details

Journal: Frontiers in Pharmacology
Published: 2026-01-07
DOI: https://doi.org/10.3389/fphar.2025.1629854
Primary Topic: Lung Cancer Treatments and Mutations
Type: article
Field-Weighted Citation Impact: 0.00

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article

Case Report: Perioperative application of trastuzumab deruxtecan in HER2 exon 20 mutation-positive non-small cell lung cancer

Heng Zhang, Jiaqi Yang, Wenzhu Li, Xiaoshu Chai et al.

Jan 7, 2026

Frontiers in Pharmacology

Lung Cancer Treatments and Mutations

article

Case Report: Perioperative application of trastuzumab deruxtecan in HER2 exon 20 mutation-positive non-small cell lung cancer

Heng Zhang, Jiaqi Yang, Wenzhu Li, Xiaoshu Chai, Zhenzhen Xiao, Lirong Liu

January 7, 2026article en

Abstract

This case shows that perioperative treatment with T-DXd could induce tumor regression and sustain remission, while MRD monitoring enables early detection of molecular progression. These findings emphasize the potential of combining T-DXd and MRD monitoring to tailor treatment to improve outcomes in <i>HER2</i>-mutant NSCLC.

Frontiers in PharmacologyVol. 16

Guangzhou University of Chinese Medicine (CN), Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)

Good health and well-being

Openalex Percentile: Top 96%

Lung Cancer Treatments and Mutations

DOI Open Access PDF OpenAlex

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Case Report: Perioperative application of trastuzumab deruxtecan in HER2 exon 20 mutation-positive non-small cell lung cancer — Heng Zhang, Jiaqi Yang, et al. · Frontiers in Pharmacology (2026) | TGRS Research Map | TGRS