Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes
The higher aperiodic component and a reduced SPR observed in aMCI relative to naMCI in APOE4 carriers may indicate an interplay between genetic predisposition, neuropathological changes, and cognitive decline. These aperiodic components, combined with APOE4 status, represent promising neurophysiological markers that may help identify individuals at elevated risk for cognitive decline or progression toward AD.
Authors
- Kahye Kim
- Jaeuk U. Kim (ORCID: https://orcid.org/0000-0003-0408-5569)
- Kun Ho Lee
- Boncho Uk Ku (ORCID: https://orcid.org/0000-0001-5520-9782)
- Joel Eyamu (ORCID: https://orcid.org/0009-0000-7423-7439)
Institutions
- Chosun University (KR)
- Korea Institute of Oriental Medicine (KR)
- Korea Brain Research Institute (KR)
- Gwangju University (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3389/fnagi.2025.1675330
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Institute of Oriental Medicine
- Ministry of Science and ICT, South Korea