Dual Escape From Disulfidptosis and Ferroptosis Drives Highly Aggressive, Hypermetabolic Hepatocellular Carcinoma
High xCT expression combined with elevated FDG uptake may identify a subset of patients with HCC who have poor prognoses and dual resistance to ferroptosis and disulfidptosis. These findings highlight the potential of xCT as both a prognostic biomarker and therapeutic target for aggressive HCC.
Authors
- Norifumi Iseda (ORCID: https://orcid.org/0000-0001-8589-0038)
- Takeo Toshima
- Junya Mita (ORCID: https://orcid.org/0000-0002-6383-792X)
- Takuro Isoda
- Kousei Ishigami (ORCID: https://orcid.org/0000-0001-8107-5570)
- Yoshiyuki Kitamura (ORCID: https://orcid.org/0000-0002-8852-2895)
- Tomoharu Yoshizumi
- Y. Oda
- Shinichi Aishima
- Shinji Itoh
Institutions
- Kyushu University (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1111/hepr.70116
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 36.44
Funders
- Japan Society for the Promotion of Science