Therapeutic Monitoring of Polymyxin B in Critically Ill Patients with Carbapenem-Resistant Organisms: Evaluation Based on Steady-State Trough and Peak Concentrations
The PMB AUC<sub>ss,24h</sub> estimated from C<sub>trough,ss</sub> and C<sub>peak,ss</sub> was closely correlated with clinical efficacy. The two-point sampling strategy based on steady-state trough and peak concentrations is applicable for therapeutic monitoring of PMB in critically ill patients.
Authors
- Y. Chen
- Mengting Yu (ORCID: https://orcid.org/0000-0003-3302-6322)
- Yu Gan (ORCID: https://orcid.org/0009-0006-2193-1199)
- Jun Yang
- Linli Xie (ORCID: https://orcid.org/0009-0001-0135-3997)
- Y C Zhao
- G. Yang
Institutions
- Army Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/dddt.s568529
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00