Contrasting immune responses in COVID-19: insights from healthcare workers and infected patients on plasmablast, pDC, and NK cell dynamics
Our findings suggest that immune dysregulation, characterized by increased plasmablasts and reduced pDC and NK cell responses, contributes to COVID-19 severity. Strong pDC and NK cell responses may confer protection against SARS-CoV-2. These insights into immune responses may inform strategies for therapeutic interventions and vaccine development.
Authors
- Roberto Pariente (ORCID: https://orcid.org/0000-0001-9323-5236)
- Laura Luna (ORCID: https://orcid.org/0000-0003-2373-8131)
- Paulette Esperanza Walo-Delgado
- Ana del Amo-de Palacios
- Javier García‐Pérez (ORCID: https://orcid.org/0000-0003-0300-1810)
- E Rodríguez-Martín
- LUISA MARÍA VILLAR
- Janepsy Díaz (ORCID: https://orcid.org/0000-0001-6016-1840)
- Sergio Serrano-Villar
- José Alcamí
- Erick De La Torre-Tarazona
- Mario Rodríguez-Dominguez
- Juan Carlos Galán
- Santiago Moreno
- Claudia Geraldine Rita
- María Fons
- Elena Moreno
- Roser Navarro-Soler
- Laura Martín-Pedraza
Institutions
- Universidad de Alcalá (ES)
- Instituto Cajal (ES)
- Instituto de Salud Carlos III (ES)
- Universidad Nebrija (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Hospital Universitario Ramón y Cajal (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1693903
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto de Salud Carlos III
- European Regional Development Fund