Proliferative double-negative T (DNT)-cell responses to PD-1 blockade therapy were positively correlated with good clinical outcomes in non-small cell lung cancer patients
Analysis of pre- and post-treatment DNT cells revealed that a higher DNT cell count was associated with better prognosis. Our findings suggest that peripheral DNT cells may serve as valuable biomarkers for monitoring clinical responses in NSCLC patients undergoing anti-PD-1 therapy.
Authors
- Ying Mu (ORCID: https://orcid.org/0000-0002-4322-2522)
- Weihong Sun (ORCID: https://orcid.org/0000-0002-2422-7440)
- Yukun Wang
- Xiaofang Wei
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Shandong Academy of Chinese Medicine (CN)
Publication Details
- Journal
- Pakistan Journal of Medical Sciences
- Published
- 2026-01-05
- DOI
- https://doi.org/10.12669/pjms.42.1.11433
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Qingdao Key Health Discipline Development Fund
- Qingdao University