Effect of Germanium(IV) and Tin(IV) Biocoordination Compounds on the Elastase Activity of Bacillus licheniformis IMB B-8008

The study of the effect of 19 biocoordination compounds of germanium (IV) and four compounds of stannum (IV) on activity of elastase of <i>Bacillus licheniformis</i> IMB B-8008, isolated from the bottom sediments of the Black Sea, showed that they have a multivector effect. Maximal stimulating effect was exhibited by [M(H<sub>2</sub>O)<sub>6</sub>][Ge<sub>2</sub>(OH)<sub>2</sub>(H<sub>2</sub>Glu)<sub>2</sub>]·nH<sub>2</sub>O (H<sub>6</sub>Glu is gluconic acid, M = Cu), which stimulated the elastase activity by 65%, whereas [Fe(phen)<sub>3</sub>]<sub>4</sub>[Ge<sub>6</sub>(μ-OH)<sub>4</sub>(μ-O)<sub>2</sub>(μ-hedp)<sub>6</sub>]·20H<sub>2</sub>O and [Fe(phen)<sub>3</sub>]<sub>2</sub>[{Sn(HMal)<sub>2</sub>(Mal)}Cl]·14H<sub>2</sub>O showed maximal inhibiting effect (100%). The inhibiting effect of these compounds did not depend on their concentrations and incubation time. The stimulating effect of [M(H<sub>2</sub>O)<sub>6</sub>][Ge<sub>2</sub>(OH)<sub>2</sub>(H<sub>2</sub>Glu)<sub>2</sub>]·nH<sub>2</sub>O (H<sub>6</sub>Glu is gluconic acid, M = Cu) was manifested only under its concentration of 0.1 %, whereas under 0.01 % it did not show any effect. The results obtained are important for the inhibition of the elastase activity of pathogenic microorganisms occurring in the seas and oceans.